Nanoscale Metrix TaylorSizer™: Precision Nanoparticle Sizing in Malaysia
High-Resolution Size Distribution for Proteins, LNPs, and Advanced Biologics
Characterizing ultra-small particles below 50 nm has traditionally been a challenge for Malaysian labs relying solely on Dynamic Light Scattering (DLS). The Nanoscale Metrix TaylorSizer™ introduces a paradigm shift in biophysical characterization. Utilizing patented Size-Distribution Taylor Dispersion Analysis (SD-TDA), it delivers a high-resolution, mass-weighted view of your sample that remains unaffected by large aggregates or environmental dust.
Whether you are developing mRNA-based lipid nanoparticles (LNPs) in a Klang Valley biotech hub or optimizing quantum dots in a Penang-based semiconductor lab, the TaylorSizer™ provides the accuracy needed for Malaysia’s most demanding R&D environments.
Whether you are developing mRNA-based lipid nanoparticles (LNPs) in a Klang Valley biotech hub or optimizing quantum dots in a Penang-based semiconductor lab, the TaylorSizer™ provides the accuracy needed for Malaysia’s most demanding R&D environments.
Why the TaylorSizer™ is the New Standard for Malaysian Research
The TaylorSizer™ excels where other techniques struggle. By measuring the broadening of a sample plug in a laminar flow, it provides an absolute measurement of the hydrodynamic radius (Rh) without requiring complex calibrations or refractive index data.
Key Performance Features:
- Ultra-Small Sensitivity: Accurately resolve populations from 0.5 nm up to 500 nm.
- Mass-Weighted Results: Unlike DLS (which is intensity-weighted), TDA is mass-weighted. This ensures that a single large aggregate won’t hide the data of your primary protein or nanoparticle.
- Complex Buffer Compatibility: Measure samples in their native state, even in high-concentration buffers, surfactants, or saline solutions common in pharmaceutical formulations.
- Nanoliter Sample Volume: Protect your most valuable samples with a microcapillary system that requires only a few nanoliters per run—ideal for early-stage drug discovery.
- Integrated Viscosity Measurement: Simultaneously determine the micro-viscosity of your formulation to assess stability and flow characteristics.
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Frequently Asked Questions (FAQ)
While DLS is excellent for quick screening, it is highly sensitive to large particles which can “blind” the instrument to smaller populations. TDA is mass-weighted and uses a flow-based system, meaning it can “see through” aggregates to give you a clear, high-resolution size distribution of your primary molecules.
Yes. One of the TaylorSizer’s greatest strengths is its ability to measure samples in their native state. High salinity, surfactants, or complex excipients do not interfere with the measurement, unlike many light-scattering techniques.
The TaylorSizer™ is designed for efficiency. Most runs are completed in just a few minutes, with automated data processing providing results immediately to keep your research timeline on track.
Absolutely. LMS Scientific Solution Sdn Bhd is the authorized distributor. We provide full installation, local application support, and technical service from our Malaysian specialists to ensure your lab performs at its peak.
FEATURES
APPLICATIONS
SPECIFICATIONS
VIDEO
FEATURES
Ultra‑High Resolution Size Distribution
- Resolves fine particle populations and multimodal distributions
- Exceptional sensitivity in the 1–50 nm range
- Ideal for ultrasmall nanoparticles, proteins, and biomolecular assemblies
- No fluorescent or chemical labeling required
- Analyze samples in their native liquid state
- Preserves true particle behavior and interactions
- Simple dilution workflows
- Compatible with a wide range of buffers and solvents
- Reduces operator time and experimental variability
- Rapid measurement cycles suitable for R&D and QC
- Excellent repeatability for routine testing and batch comparison
- Supports method development and validation
- Complements DLS, NTA, and microscopy
- Provides additional insight into size distribution and aggregation
- Ideal for confirmatory and comparative studies
APPLICATIONS
Biotechnology & Life Sciences
- Protein size distribution and aggregation analysis
- Characterization of lipid nanoparticles (LNPs)
- Extracellular vesicles (EVs) and biologics research
- Stability studies under formulation or stress conditions
- Formulation screening and optimization
- Batch‑to‑batch consistency testing
- Early detection of aggregation and degradation
- Support for regulatory‑driven QC workflows
- Nanoparticle coating and functionalization studies
- Size monitoring during synthesis and scale‑up
- Quality control of engineered nanomaterials
- Research into dispersion stability
SPECIFICATIONS
| Parameter | Specification |
| Pressure range | 10–3500 mbar, 1 mbar resolution |
| Inlet Trays | Buffer: 50 positions; Sample: 50 positions |
| Outlet Waste Vial | 20 positions |
| Autosampler temperature control | 5–55 °C |
| Temperature of Capillary Oven Compartment | 15–55 °C |
| Real-time UV-VIS diode array detector | 190–610 nm (UV version); 190–1010 nm (VIS version) |
| Laser Induced Fluorescence | Multiple wavelengths available (480, 535, 640 nm) |
| Software tools | Viscosity measurement; Method development assistance using abacuses |
| Size (W × D × H) | 43 × 48 × 66 cm |
| Weight | 43 kg |
| Power | 120–240 VAC, 50/60 Hz |
- Simple and intuitive software interface for instrument control and data analysis
- Automatic relative quantification of particle subpopulations and polydispersity index (PDI) provided at the end of each measurement
- Clear data presentation through tabulated results, SD-TDA size distribution plots, and real-time Taylorgram monitoring
- Advanced data processing using a patented algorithm to compute accurate size distributions directly from experimental Taylorgrams
- Integrated viscosity measurement tool for extended biophysical characterization
- Dedicated method development assistance tool, incorporating Taylor-based abacus guidance for optimized and reproducible measurements
VIDEO
TAYLOR DISPERSION ANALYZERS (TDA)
TAYLOR DISPERSION ANALYZERS (TDA)