RT814 Automated Transdermal Diffusion System
Distributed in Malaysia by LMS Scientific Solution Sdn Bhd, the RT814 streamlines the complexities of semi-solid dosage form testing, ensuring high repeatability and full regulatory compliance for pharmaceutical R&D and quality control laboratories.
Why Choose the Raytor RT814?
Key Features and Benefits
- High Throughput Efficiency: Equipped with 14 diffusion cells (2 groups of 7), allowing for simultaneous testing of multiple formulations alongside a control.
- Automated Sampling Precision: Features a high-precision syringe pump system that ensures accurate sampling volumes and automatic media replenishment to maintain “sink conditions.”
- Superior Temperature Control: Utilizing a dry-heat heating manifold, the system provides uniform temperature distribution across all cells with an accuracy of ±0.2°C.
- Data Integrity & Compliance: Fully compliant with FDA 21 CFR Part 11 requirements, featuring multi-level user management, audit trails, and secure data storage.
- Versatile Cell Compatibility: Supports various Franz cell sizes and volumes, making it adaptable for skin permeation studies, patches, gels, and creams
Advanced Software Capabilities
- Real-time Monitoring: Track stirring speeds and temperature profiles throughout the duration of the test.
- Method Storage: Save and recall complex testing protocols to ensure consistency across different lab technicians.
- Automated Cleaning: Built-in automated cleaning cycles reduce downtime between experimental runs.
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Frequently Asked Questions (FAQ)
Yes. The Raytor RT814 and its associated Franz diffusion cells are designed in strict accordance with USP <1724> guidelines for semi-solid drug products performance testing.
Absolutely. The RT814 is a versatile platform capable of performing In Vitro Release Testing (IVRT) for quality control and In Vitro Permeation Testing (IVPT) using synthetic membranes or biological skin samples.
The system utilizes specialized cell covers and a sealed sampling manifold to minimize evaporation, ensuring the concentration of the receptor medium remains accurate throughout long-term studies (up to 72 hours or more).
The RT814 is engineered for maximum versatility across a wide range of topical and transdermal drug delivery systems (TDDS). It is ideally suited for:
- Formulations: Creams, ointments, gels, lotions, transdermal patches, and even innovative delivery systems like microneedles or nano-emulsions.
- Membranes: The system supports both synthetic membranes (commonly used for IVRT to ensure batch-to-batch consistency) and biological skin samples (such as human or porcine skin used in IVPT to predict clinical absorption).
This flexibility makes the RT814 a critical tool for pharmaceutical companies in Malaysia performing bioequivalence studies for generic topical products.
As the authorized partner, LMS Scientific Solution Sdn Bhd provides end-to-end support, including installation, IQ/OQ validation, user training, and localized technical maintenance.
| Number of Cells | 14 (Two independent zones of 7) |
| Diffusion cell volume | 9, 10, 12mL |
| Stirring Speed | 200 – 900 RPM (Accuracy ≤±10%) |
| Temperature Range | Room Temp. ~ 50°C (Accuracy ≤±0.5°C) |
| Sampling Volume | 1 mL – 10 mL |
| Media Replacement | Automatic and Synchronous |
| Software | Raytor Diffusion Workstation (21 CFR Part 11) |